用于鉴别牛新发生的 C、L 和新型克雅氏病的四种独立的朊病毒蛋白参数。
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
机构信息
Central Veterinary Institute of Wageningen UR, P.O. Box 65, 8200 AB Lelystad, The Netherlands.
出版信息
J Clin Microbiol. 2011 Aug;49(8):3026-8. doi: 10.1128/JCM.01102-11. Epub 2011 Jun 15.
Abstract
In anticipation of the emergence of more variants of bovine spongiform encephalopathy (BSE), a semiquantitative display of the following four independent molecular diagnostic prion parameters was designed: N terminus, proteinase K (PK) resistance, glycoprofile, and mixed population. One H BSE case, three L BSE cases, six C BSE cases, and one unusual classical BSE (C BSE) case are reported.
摘要
为了应对更多牛海绵状脑病（BSE）变异体的出现，设计了以下四个独立分子诊断朊病毒参数的半定量显示：N 端、蛋白酶 K（PK）抗性、糖基化谱和混合群体。本文报告了 1 例 H 型 BSE 病例、3 例 L 型 BSE 病例、6 例 C 型 BSE 病例和 1 例不寻常的经典 BSE（C BSE）病例。
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