Frost L, Skajaa K, Hvidman L E, Fay S J, Larsen P M
Department of Obstetrics and Gynecology, Aarhus Municipal Hospital, Denmark.
Br J Obstet Gynaecol. 1990 Jul;97(7):626-30. doi: 10.1111/j.1471-0528.1990.tb02552.x.
Women with histologically confirmed cervical intraepithelial neoplasia grade 2 (CIN 2) were treated in a double blind investigation of treatment with intralesioneal interferon alpha-2b (Intron a). Before treatment commenced, the existence and the types of human papilloma-virus (HPV) were assessed in [35S] methionine-labelled cervical biopsies by the determination of specific protein markers. Pronounced side effects occurred in all the women treated with interferon and the trial was stopped when it became apparent that there were no obvious beneficial effects. No positive benefits of interferon treatment were detected on either the CIN 2 or on the persistence of HPV types. It is concluded that intralesioneal injection of interferon has no place in the treatment of CIN.
对组织学确诊为宫颈上皮内瘤变2级（CIN 2）的女性进行了一项关于病灶内注射干扰素α-2b（安特罗）治疗的双盲研究。在开始治疗前，通过测定特定蛋白质标志物，在[35S]甲硫氨酸标记的宫颈活检组织中评估人乳头瘤病毒（HPV）的存在情况及类型。所有接受干扰素治疗的女性均出现明显副作用，而且当明显看不到明显的有益效果时，试验停止。未检测到干扰素治疗对CIN 2或HPV类型的持续存在有任何积极益处。得出的结论是，病灶内注射干扰素在CIN治疗中没有地位。
