Dunham A M, McCartney J C, McCance D J, Taylor R W
St Thomas' Hospital, London.
J R Soc Med. 1990 Aug;83(8):490-2. doi: 10.1177/014107689008300804.
In this controlled prospective study, 14 patients with cervical intraepithelial neoplasia (CIN) were observed for one month to exclude spontaneous regression, and then seven patients were treated twice-weekly with perilesional injections of alpha-interferon. Both groups were monitored colposcopically, and advised to use the contraceptive sheath. Cervical smears and biopsies for histology and viral studies were taken before and after the study. There was an improvement of six out of seven of the study group, with two complete cures. Koilocytosis disappeared if it had been present initially, as did human papillomavirus (HPV) 16. By contrast, three control cases showed improvement, but there were no cures, and one case deteriorated; Koilocytosis (2 cases) did not change; HPV 16 disappeared in two controls and appeared in one. A new focus of dysplasia appeared in a part of the transformation zone not being treated with alpha-interferon in one of the study cases, illustrating the advisability of treating the whole transformation zone in CIN.
在这项对照前瞻性研究中，对14例宫颈上皮内瘤变（CIN）患者观察了1个月以排除自然消退情况，然后对7例患者每周进行两次病灶周围注射α-干扰素治疗。两组均接受阴道镜监测，并建议使用避孕套。在研究前后采集宫颈涂片及组织学和病毒学研究的活检样本。研究组7例中有6例病情改善，2例完全治愈。若最初存在挖空细胞，则其消失，人乳头瘤病毒（HPV）16也是如此。相比之下，3例对照病例有改善，但无治愈情况，1例病情恶化；2例对照病例的挖空细胞未改变；HPV 16在2例对照中消失，在1例中出现。1例研究病例在未用α-干扰素治疗的转化区部分出现了新的发育异常病灶，这说明对CIN治疗整个转化区是明智的。
