格拉司琼、ICS 205 - 930和昂丹司琼对十二指肠扩张诱发的内脏疼痛反射的影响。 - Suppr

The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension.

Moss H E, Sanger G J

Beecham Pharmaceuticals, Medicinal Research Centre, Harlow, Essex.

Br J Pharmacol. 1990 Jul;100(3):497-501. doi: 10.1111/j.1476-5381.1990.tb15836.x.

Distension of the duodenum in anaesthetized rats, by rapid application of intraluminal pressures (10-75 cmH2O), evoked falls in diastolic blood pressure and intragastric pressure. 2. The distension-induced responses were blocked by pretreatment with morphine (20 mg kg-1, s.c.), an action reversible by injection of naloxone (5 mg kg-1, i.v.). 3. Bilateral cervical vagotomy reduced the distension-evoked fall in intragastric pressure but had no effect on the corresponding fall in blood pressure. 4. Granisetron or ICS 205-930 (1-1000 micrograms kg-1, i.v.) had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell-shaped dose-response relationship. Ondansetron (1-1000 micrograms kg-1, i.v.) did not reduce the reflex responses. 5. These results show that the 5-HT3 receptor antagonists used exerted different effects on the reflex responses to duodenal distension.

在麻醉大鼠中，通过快速施加腔内压力（10 - 75 cmH₂O）使十二指肠扩张，可引起舒张压和胃内压下降。2. 用吗啡（20 mg kg⁻¹，皮下注射）预处理可阻断扩张诱导的反应，注射纳洛酮（5 mg kg⁻¹，静脉注射）可使该作用逆转。3. 双侧颈迷走神经切断术可减轻扩张引起的胃内压下降，但对相应的血压下降无影响。4. 格拉司琼或ICS 205 - 930（1 - 1000 μg kg⁻¹，静脉注射）对十二指肠腔内压力无影响，但以钟形剂量反应关系减弱对扩张的反应。昂丹司琼（1 - 1000 μg kg⁻¹，静脉注射）不减弱反射反应。5. 这些结果表明，所使用的5 - HT₃受体拮抗剂对十二指肠扩张的反射反应产生不同影响。

格拉司琼、ICS 205 - 930和昂丹司琼对十二指肠扩张诱发的内脏疼痛反射的影响。