Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Nat Rev Cancer. 2011 Jun 16;11(7):523-32. doi: 10.1038/nrc3081.
Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell's survival and reproduction. Because the molecular logic of these circuits is difficult to comprehend by intuitive reasoning alone, we present some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid our understanding of their susceptibility or resistance to endocrine therapy.
乳腺癌和其他组织的癌症是由细胞在其存活或死亡、增殖或静止、损伤修复或旁路选择方面的异常决策引起的。这些决策是由分子信号网络做出的，这些网络处理来自乳腺癌细胞内外的信息，并启动决定细胞存活和繁殖的反应。由于这些电路的分子逻辑仅凭直观推理难以理解，我们提出了一些乳腺癌细胞基本决策电路的初步数学模型，这可能有助于我们理解它们对内分泌治疗的敏感性或耐药性。
