研究自毁型连接子在设计过氧化氢激活金属蛋白酶抑制剂中的应用。
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
出版信息
Chem Commun (Camb). 2011 Jul 28;47(28):7968-70. doi: 10.1039/c1cc12526e. Epub 2011 Jun 16.
Abstract
A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
摘要
研究了一系列具有不同连接策略的自毁型硼酸酯保护的甲基水杨酸盐和金属结合基团，用于设计基质金属蛋白酶原抑制剂。
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