由过氧亚硝酸盐和过氧化氢激活的基于硼酸盐的生物活性化合物。
Boronate-Based Bioactive Compounds Activated by Peroxynitrite and Hydrogen Peroxide.
作者信息
Rola Monika, Zielonka Jacek, Smulik-Izydorczyk Renata, Pięta Jakub, Pierzchała Karolina, Sikora Adam, Michalski Radosław
机构信息
Institute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
出版信息
Redox Biochem Chem. 2024 Dec;10. doi: 10.1016/j.rbc.2024.100040. Epub 2024 Aug 14.
Abstract
Boronates react directly and stoichiometrically with peroxynitrite and hydrogen peroxide. For this reason, boronates have been widely used as peroxynitrite- and hydrogen peroxide-sensitive moieties in various donors of bioactive compounds. So far, numerous boronate-based prodrugs and theranostics have been developed, characterized, and used in biological research. Here, the kinetic aspects of their activation are discussed, and the potential benefits of modifying their original structure with a boronic or boronobenzyl moiety are described.
摘要
硼酸酯能与过氧亚硝酸根和过氧化氢直接发生化学计量反应。因此，硼酸酯在各种生物活性化合物供体中被广泛用作对过氧亚硝酸根和过氧化氢敏感的部分。到目前为止，已经开发、表征了许多基于硼酸酯的前药和诊疗试剂，并将其用于生物学研究。在此，讨论了它们活化的动力学方面，并描述了用硼酸或硼苄基部分修饰其原始结构的潜在益处。
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