Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
Neurol Sci. 2011 Dec;32(6):1209-12. doi: 10.1007/s10072-011-0648-7. Epub 2011 Jun 16.
A 70-year-old woman developed paraneoplastic cerebellar degeneration (PCD) due to P/Q-type and N-type voltage-gated calcium channel antibodies and small cell lung cancer, the main clinical manifestations of which were severe positioning vertigo and vomiting. Loss of the visual suppression of caloric nystagmus, spontaneous downbeat nystagmus, periodic alternating nystagmus, and positioning vertigo in our patient most probably corresponds to the cerebellar flocculus/paraflocculus lesion caused by PCD.
一位 70 岁女性因 P/Q 型和 N 型电压门控钙通道抗体和小细胞肺癌而发生副肿瘤性小脑变性（PCD），其主要临床表现为严重的定位性眩晕和呕吐。我们的患者存在冷刺激眼球震颤的视觉抑制丧失、自发性下跳性眼球震颤、周期性交替性眼球震颤和位置性眩晕，这些最可能与 PCD 引起的小脑绒球/副绒球病变相对应。
