Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Cancer Sci. 2011 Oct;102(10):1756-60. doi: 10.1111/j.1349-7006.2011.02010.x. Epub 2011 Jul 26.
Hedgehog (Hh) signaling is an important factor in growth and patterning during embryonic development. A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling pathway, might lead to the onset of glioblastoma, basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. Recently, Hh signaling has been reported to be activated in a ligand-dependent manner, contributing to carcinogenesis and cancer progression. Hedgehog signaling is reactivated in various types of cancer, and this contributes to cancer progression by facilitating proliferation, invasion and cell survival. Moreover, Hh signaling is associated with several other signaling pathways that contribute to cancer progression. These observations indicate that controlling Hh signaling might become a target for novel molecular targeting therapy.
Hedgehog（Hh）信号通路是胚胎发育过程中生长和模式形成的重要因素。Patched、Smoothened 或 Gli1 的突变，这些基因调节 Hh 信号通路，可能导致神经胶质瘤、基底细胞癌、髓母细胞瘤和横纹肌肉瘤的发生。最近，据报道 Hh 信号通路以配体依赖的方式被激活，有助于致癌作用和癌症进展。Hh 信号通路在各种类型的癌症中被重新激活，通过促进增殖、侵袭和细胞存活来促进癌症进展。此外，Hh 信号通路与其他有助于癌症进展的信号通路有关。这些观察结果表明，控制 Hh 信号通路可能成为新的分子靶向治疗的靶点。
