Singh Kuldeep, Sethi Pranshul, Gupta Jeetendra Kumar, Dubey Anubhav, Sharma Mukesh Chandra, Jain Divya, Bhatt Alok, Kumar Shivendra
Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
Department of Pharmacology, College of Pharmacy, Shri Venkateshwara University, Gajraula, Uttar Pradesh, India.
Curr Stem Cell Res Ther. 2025;20(5):494-508. doi: 10.2174/011574888X341526250113064851.
Glioblastoma (GBM) is recognized as the most aggressive and lethal form of primary brain tumor, characterized by rapid proliferation and significant resistance to conventional therapies. Recent studies have illuminated the complex role of Neural Stem Cells (NSCs) in both the progression and treatment of GBM. This review examines the specific molecular pathways influenced by NSCs, focusing on critical signaling cascades such as Notch, P13K, and SHH, which are implicated in tumor development and maintenance. Furthermore, we explore the dual role of NSCs in glioblastoma, where they can act as both facilitators of tumorigenesis and potential agents of tumor suppression, depending on the microenvironmental context. Understanding these intricate interactions is essential for developing innovative therapeutic strategies that target NSCs in GBM. This review aims to provide a comprehensive overview of current knowledge and to identify future research directions in this promising field, ultimately contributing to the advancement of personalized treatment approaches for patients with glioblastoma.
胶质母细胞瘤（GBM）被认为是原发性脑肿瘤中最具侵袭性和致命性的形式，其特征是快速增殖以及对传统疗法具有显著抗性。最近的研究揭示了神经干细胞（NSCs）在GBM的进展和治疗中所起的复杂作用。本综述探讨了受神经干细胞影响的特定分子途径，重点关注关键信号级联反应，如Notch、P13K和SHH，这些信号级联反应与肿瘤的发生和维持有关。此外，我们还探讨了神经干细胞在胶质母细胞瘤中的双重作用，根据微环境背景，它们既可以作为肿瘤发生的促进者，也可以作为潜在的肿瘤抑制因子。了解这些复杂的相互作用对于开发针对GBM中神经干细胞的创新治疗策略至关重要。本综述旨在全面概述当前的知识，并确定这一有前景领域未来的研究方向，最终推动胶质母细胞瘤患者个性化治疗方法的进步。
