Goh K T, Ooi P L, Miyamura K, Ogino T, Yamazaki S
Quarantine and Epidemiology Department, Ministry of the Environment, Singapore.
J Med Virol. 1990 Jul;31(3):245-7. doi: 10.1002/jmv.1890310313.
Epidemics of acute haemorrhagic conjunctivitis caused by a variant of coxsackievirus A24 (CA24v) and enterovirus 70 (EV70) have occurred periodically in Singapore. A seroepidemiological survey conducted before the CA24v epidemic in 1985 and in the midst of the EV70 epidemic in 1983 showed a neutralising antibody prevalence (greater than or equal to 1:4) of 19.1% and 66.9% to CA24v and EV70, respectively. The seropositivity rate to both viruses was highest in children 10-14 years of age, but no sex or ethnic difference was noted. It appears from the data that an epidemic could be triggered when the herd immunity of the population falls below a critical level. There was a significant correlation in seroprevalence between CA24v and EV70 (P = 7.75 x 10(-3).
由A24型柯萨奇病毒变异株（CA24v）和肠道病毒70型（EV70）引起的急性出血性结膜炎疫情在新加坡周期性爆发。1985年CA24v疫情之前以及1983年EV70疫情期间进行的血清流行病学调查显示，针对CA24v和EV70的中和抗体流行率（大于或等于1:4）分别为19.1%和66.9%。10至14岁儿童对这两种病毒的血清阳性率最高，但未发现性别或种族差异。从数据来看，当人群的群体免疫力降至临界水平以下时，可能引发疫情。CA24v和EV70的血清流行率之间存在显著相关性（P = 7.75 x 10(-3)）。
