Chou M Y, Malison M D
CDC, Atlanta, GA 30333.
Am J Epidemiol. 1988 Apr;127(4):795-800. doi: 10.1093/oxfordjournals.aje.a114861.
Outbreaks of acute hemorrhagic conjunctivitis caused by enterovirus 70 and several serotypes of adenovirus have occurred in Taiwan since 1971. In 1980-1981, there was a pandemic of acute hemorrhagic conjunctivitis in southeast Asia caused by coxsackie A24 variant (CA24v); however, this virus did not affect Taiwan. In October 1985, CA24v was isolated for the first time from patients with acute hemorrhagic conjunctivitis in southern Taiwan. The following summer, a large epidemic of acute hemorrhagic conjunctivitis due to CA24v occurred. An epidemiologic investigation of patients seen at one ophthalmology clinic in Taipei City revealed that school-age children were the most likely group to introduce illness into households (p less than 0.001) and that males were more often household index cases than were females (p less than 0.01). Multiple case households tended to be more crowded (3.0 vs. 2.5 persons per bathroom; p less than 0.05) and had illness introduced by younger family members (median age of index case = 10 vs. 17 years; p less than 0.01). It is unknown whether this outbreak is an isolated occurrence or represents another resurgence of CA24v in the area.
自1971年以来，台湾地区曾爆发由肠道病毒70型和几种腺病毒血清型引起的急性出血性结膜炎。1980 - 1981年，东南亚地区爆发了由柯萨奇A24变异株（CA24v）引起的急性出血性结膜炎大流行；然而，这种病毒并未影响台湾地区。1985年10月，首次从台湾南部急性出血性结膜炎患者中分离出CA24v。次年夏天，发生了由CA24v引起的急性出血性结膜炎大流行。对台北市一家眼科诊所就诊患者的流行病学调查显示，学龄儿童是最有可能将疾病带入家庭的群体（p < 0.001），且男性作为家庭首例病例的情况比女性更为常见（p < 0.01）。多病例家庭往往更为拥挤（每间浴室3.0人对2.5人；p < 0.05），且由较年轻家庭成员带入疾病（首例病例的中位年龄 = 10岁对17岁；p < 0.01）。此次疫情是孤立事件还是该地区CA24v的再次流行尚不清楚。
