Hadjizacharia Pantelis, O'Keeffe Terence, Brown Carlos V R, Inaba Kenji, Salim Ali, Chan Linda S, Demetriades Demetrios, Rhee Peter
Division of Trauma, University of Arizona, Tucson, Arizona 85724-5063, USA.
Am Surg. 2011 May;77(5):634-9. doi: 10.1177/000313481107700526.
The purpose of this study is to determine the incidence, risk factors, and outcomes after the development of an atrial arrhythmia (AA) in trauma patients admitted to the intensive care unit (ICU). We performed a retrospective study of more than 7 years of trauma patients admitted to the ICU at an urban, academic Level I trauma center. Patients with AA, defined as atrial fibrillation, atrial flutter, or paroxysmal supraventricular tachycardia, were compared with patients without AA. Groups were compared by univariate and multivariate analysis. Three thousand, four hundred and ninety-nine trauma patients were admitted to the ICU during the study period and 210 (6%) developed an AA. AA patients were more likely to sustain blunt trauma, were older, more often female, more severely injured, and sustained more head injuries. The only independent risk factor for developing an AA was age > 55 years (odds ratio = 4.6, P < 0.01). Mortality was higher in the AA group (33% vs. 14%, P < 0.01) and AA was an independent risk factor for mortality (odds ratio = 1.7, P = 0.01). Twenty-eight per cent (n = 59) of AA patients received beta-blockers in the postinjury period, and these patients had lower mortality (22% vs. 37%, P = 0.04). AA occurs in 6 per cent of trauma patients admitted to the ICU. Developing an AA is an independent risk factor for mortality after trauma. Beta-blocker therapy was associated with decreased mortality in trauma patients with AA.
本研究的目的是确定入住重症监护病房(ICU)的创伤患者发生房性心律失常(AA)后的发病率、危险因素及预后。我们对一家城市一级学术创伤中心7年多来入住ICU的创伤患者进行了一项回顾性研究。将被定义为房颤、房扑或阵发性室上性心动过速的AA患者与无AA的患者进行比较。通过单因素和多因素分析对各组进行比较。在研究期间,3499名创伤患者入住ICU,其中210例(6%)发生了AA。AA患者更易遭受钝性创伤,年龄更大,女性更多,受伤更严重,头部受伤更多。发生AA的唯一独立危险因素是年龄>55岁(比值比=4.6,P<0.01)。AA组的死亡率更高(33%对14%,P<0.01),且AA是死亡的独立危险因素(比值比=1.7,P=0.01)。28%(n=59)的AA患者在伤后接受了β受体阻滞剂治疗,这些患者的死亡率较低(22%对37%,P=0.04)。入住ICU的创伤患者中有6%发生AA。发生AA是创伤后死亡的独立危险因素。β受体阻滞剂治疗与AA创伤患者死亡率降低相关。