重症监护病房中的神经保护剂：重症监护病房中的神经保护剂。
Neuroprotective Agents in the Intensive Care Unit: -Neuroprotective Agents in ICU.
作者信息
Panahi Yunes, Mojtahedzadeh Mojtaba, Najafi Atabak, Rajaee Seyyed Mahdi, Torkaman Mohammad, Sahebkar Amirhossein
机构信息
Clinical Pharmacy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Pharmacopuncture. 2018 Dec;21(4):226-240. doi: 10.3831/KPI.2018.21.026. Epub 2018 Dec 31.
Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.
神经保护或预防神经元丢失是一个由多种细胞途径介导的复杂分子过程。尤其是在过去几十年中，已有使用不同药理剂作为神经保护剂的报道。这些神经保护剂通过抑制炎症过程和细胞凋亡、减轻氧化应激以及减少自由基来发挥作用。控制这种有害的分子过程对于减少神经元损伤至关重要，并且与改善重症监护病房患者的功能结局和恢复相关。本研究综述了神经保护剂及其针对中枢神经系统损伤的作用机制。
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