Stanford University School of Medicine, Li Ka Shing Building, 291 Campus Drive, Stanford, CA 94305, USA.
Clin Dermatol. 2011 Jul-Aug;29(4):398-411. doi: 10.1016/j.clindermatol.2011.01.009.
The dermal-epidermal basement membrane is a complex assembly of proteins that provide adhesion and regulate many important processes such as development, wound healing, and cancer progression. This contribution focuses on the structure and function of individual components of the basement membrane, how they assemble together, and how they participate in human tissues and diseases, with an emphasis on skin involvement. Understanding the composition and structure of the basement membrane provides insight into the pathophysiology of inherited blistering disorders, such as epidermolysis bullosa, and acquired bullous diseases, such as the pemphigoid group of autoimmune diseases and epidermolysis bullosa acquisita.
皮肤-表皮基底膜是一组复杂的蛋白质，提供粘附并调节许多重要的过程，如发育、伤口愈合和癌症进展。本贡献重点介绍基底膜的各个组成部分的结构和功能，它们如何组装在一起，以及它们如何参与人体组织和疾病，重点是皮肤受累。了解基底膜的组成和结构为遗传性水疱性疾病（如大疱性表皮松解症）和获得性大疱性疾病（如天疱疮组自身免疫性疾病和获得性大疱性表皮松解症）的病理生理学提供了深入的了解。
