Department of Dermatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizmann Street, Tel-Aviv University, Tel Aviv 64239, Israel.
Clin Dermatol. 2011 Jul-Aug;29(4):455-7. doi: 10.1016/j.clindermatol.2011.01.016.
Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. The diagnosis of drug-induced pemphigus is challenging. Patients have often been exposed to multiple drugs, and some drugs may have a prolonged latency period between exposure and onset of the disease. The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test has been shown to be of diagnostic value in drug-induced skin reactions. Cessation of the offending drug may alleviate the clinical manifestations and reduce the need for medical treatment.
天疱疮是一种自身免疫性大疱性疾病，可能受到遗传和外源性因素的影响。药物是天疱疮的主要致病因素。需要详细询问病史，以找到致病药物。药物诱导性天疱疮的诊断具有挑战性。患者通常接触过多种药物，并且一些药物在暴露于药物和发病之间可能存在较长的潜伏期。体外干扰素-γ（IFN-γ）释放试验已被证明对药物诱导的皮肤反应具有诊断价值。停止使用致病药物可能会缓解临床表现并减少对药物治疗的需求。
