Department of Medical Biology and Genetics, Ondokuz Mayis University, Faculty of Medicine, 55139, Samsun, Turkey.
Pathol Res Pract. 2011 Jul 15;207(7):423-7. doi: 10.1016/j.prp.2011.05.005. Epub 2011 Jun 15.
High levels of SOX4 gene expression have been reported in a variety of human cancers. The protein may function in the apoptosis pathway, leading to cell death as well as to tumorigenesis. The aim of this study was to investigate the levels of SOX4 expression in bladder cancer. Urinary bladder tumor samples were obtained from 57 bladder cancer and 13 normal bladder biopsies. The levels of SOX4 expression in bladder cancer were determined by immunohistochemistry and real-time PCR. SOX4 gene expression was increased 2.2 times in bladder tumors as compared with normal tissue. The presence of protein was confirmed by immunostaining. There were significant differences between immunostaining of bladder tumors and normal bladder tissue (P=0.001). The present data suggest that SOX4 gene may have a role in bladder cancer tumorigenesis.
SOX4 基因表达水平在多种人类癌症中均有报道。该蛋白可能在凋亡途径中发挥作用，导致细胞死亡和肿瘤发生。本研究旨在探讨膀胱癌中 SOX4 表达水平。收集 57 例膀胱癌和 13 例正常膀胱活检组织的尿液膀胱肿瘤样本。通过免疫组织化学和实时 PCR 检测膀胱癌中 SOX4 的表达水平。与正常组织相比，膀胱癌中 SOX4 基因表达增加了 2.2 倍。免疫染色证实了蛋白的存在。膀胱癌的免疫染色与正常膀胱组织之间存在显著差异（P=0.001）。本研究数据表明，SOX4 基因可能在膀胱癌发生中起作用。
