甲苯对用GABA能药物预处理的大鼠前庭和视动眼系统的影响。

The effect of toluene on the vestibulo- and opto-oculomotor system in rats, pretreated with GABAergic drugs.

作者信息

Tham R, Larsby B, Eriksson B, Niklasson M

机构信息

Department of Otolaryngology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.

出版信息

Neurotoxicol Teratol. 1990 Jul-Aug;12(4):307-11. doi: 10.1016/0892-0362(90)90048-h.

DOI:10.1016/0892-0362(90)90048-h

PMID:2168015

Abstract

Toluene, an aromatic solvent, prolongs the duration of nystagmus induced by a rotatory acceleration or by an optokinetic stimulation in the pigmented rat. Baclofen, an agonist of GABAB receptors, and 4,5,6,7-tetrahydroisoxazolo[5,4-c]-pyridin-3-ol (THIP), an agonist of GABAA receptors are able to block this toluene effect on the vestibular system. On the contrary diazepam, which by itself causes an evident reduction of the duration of acceleratory nystagmus, is not able to block the toluene effect. The results indicate that the toluene effect is related to GABA transmission and that the solvent interacts by a rather receptor specific mechanism of action.

摘要

甲苯是一种芳香族溶剂，可延长有色大鼠因旋转加速或视动刺激诱发的眼球震颤持续时间。巴氯芬是一种GABAB受体激动剂，4,5,6,7 - 四氢异恶唑并[5,4 - c] - 吡啶 - 3 - 醇（THIP）是一种GABAA受体激动剂，它们能够阻断甲苯对前庭系统的这种作用。相反，地西泮本身会明显缩短加速性眼球震颤的持续时间，但无法阻断甲苯的作用。结果表明，甲苯的作用与γ-氨基丁酸（GABA）传递有关，且该溶剂通过一种相当具有受体特异性的作用机制相互作用。