Larsby B, Tham R, Eriksson B, Odkvist L M
Acta Otolaryngol. 1986 May-Jun;101(5-6):422-8. doi: 10.3109/00016488609108627.
The short-term effect of exposure to toluene on the vestibulo- and opto-oculomotor system in rats was investigated. Stimulation of the vestibulo- and opto-oculomotor system was either a constant rotatory acceleration, a sinusoidal oscillation, a randomized oscillation or an optokinetic stimulation. Eye movements in response to the different stimulations were recorded by EOG and fed into a computer for analysis. Due to toluene exposure the slow phase velocity gain during constant acceleration increased and the post-acceleratory nystagmus response was prolonged. The optokinetic gain at stimulation velocities above 10 deg/sec decreased during toluene exposure. Toluene also prolonged the duration of optokinetic after- and after-afternystagmus. The findings in this study strongly suggest an effect of toluene on the cerebellum.
研究了大鼠接触甲苯对前庭和视动眼系统的短期影响。前庭和视动眼系统的刺激方式包括持续旋转加速、正弦振荡、随机振荡或视动刺激。通过眼电图记录对不同刺激的眼球运动，并输入计算机进行分析。由于接触甲苯，持续加速过程中的慢相速度增益增加，加速后眼震反应延长。在甲苯暴露期间，刺激速度高于10度/秒时的视动增益降低。甲苯还延长了视动后眼震和后后眼震的持续时间。本研究结果强烈表明甲苯对小脑有影响。
