Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Trends Endocrinol Metab. 2011 Oct;22(10):394-403. doi: 10.1016/j.tem.2011.05.001. Epub 2011 Jun 15.
Insulin resistance is a major characteristic of obesity and type 2 diabetes, and develops in multiple organs, including the heart. Compared with its role in other organs, the physiological role of insulin resistance in the heart is not well understood. The heart uses lipid as a primary fuel, but glucose becomes an important source of energy in ischemia. The impaired ability to utilize glucose might contribute to cell death and abnormal function in the diabetic heart. Recent discoveries regarding the role of inflammation, mitochondrial dysfunction and endoplasmic reticulum (ER) stress in obesity have advanced our understanding of how insulin resistance develops in peripheral organs. In this review, we examine these findings in relation to the diabetic heart to provide new insights into the mechanism of cardiac insulin resistance.
胰岛素抵抗是肥胖和 2 型糖尿病的主要特征，可发生在多个器官，包括心脏。与在其他器官中的作用相比，胰岛素抵抗在心脏中的生理作用尚不清楚。心脏以脂质作为主要燃料，但在缺血时葡萄糖成为重要的能量来源。葡萄糖利用能力受损可能导致糖尿病心脏中的细胞死亡和功能异常。最近关于炎症、线粒体功能障碍和内质网（ER）应激在肥胖中的作用的发现，促进了我们对周围器官中胰岛素抵抗发展的理解。在这篇综述中，我们研究了这些发现与糖尿病心脏的关系，以期为心脏胰岛素抵抗的机制提供新的见解。
