一种快速收敛的集成他汀核心的合成方法。

A rapid and convergent synthesis of the integrastatin core.

机构信息

The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA 91125, USA.

出版信息

Org Biomol Chem. 2011 Aug 7;9(15):5354-7. doi: 10.1039/c1ob05725a. Epub 2011 Jun 16.

DOI:10.1039/c1ob05725a

PMID:21681334

Abstract

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

摘要

集成他汀天然产物的四环核心已通过收敛和快速的方式制备。我们的策略依赖于钯 (II)-催化的氧化环化反应来形成天然产物核心的中环 [3.3.1]-二氧杂环丁烷。总的来说，从已知化合物出发，仅通过 4 步线性反应就完成了核心的构建。