The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA 91125, USA.
Org Biomol Chem. 2011 Aug 7;9(15):5354-7. doi: 10.1039/c1ob05725a. Epub 2011 Jun 16.
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.
集成他汀天然产物的四环核心已通过收敛和快速的方式制备。我们的策略依赖于钯 (II)-催化的氧化环化反应来形成天然产物核心的中环 [3.3.1]-二氧杂环丁烷。总的来说，从已知化合物出发，仅通过 4 步线性反应就完成了核心的构建。
