Jacobson J G, Ruffner K L, Kosz-Vnenchak M, Hwang C B, Wobbe K K, Knipe D M, Coen D M
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
J Virol. 1993 Nov;67(11):6903-8. doi: 10.1128/JVI.67.11.6903-6908.1993.
From marker rescue, sequencing, transcript, and latency analyses of the thymidine kinase-negative herpes simplex virus mutant dlsactk and studies using the thymidine kinase inhibitor Ro 31-5140, we infer that the virus-encoded thymidine kinase is required in murine trigeminal ganglia for acute replication and lytic gene expression, for increasing the numbers of cells expressing latency-associated transcripts, and for reactivation from latent infection.
通过对胸苷激酶阴性单纯疱疹病毒突变体dlsactk进行标记拯救、测序、转录本和潜伏期分析，并使用胸苷激酶抑制剂Ro 31-5140进行研究，我们推断病毒编码的胸苷激酶在小鼠三叉神经节中对于急性复制和裂解基因表达、增加表达潜伏期相关转录本的细胞数量以及从潜伏感染中重新激活是必需的。
