Min Jung-Ah, Lee Heon-Jeong, Lee Seung-Hwan, Park Young-Min, Kang Seung-Gul, Park Young-Gyu, Chae Jeong-Ho
Department of Psychiatry, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
Department of Psychiatry and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2017 Nov 30;15(4):402-406. doi: 10.9758/cpn.2017.15.4.402.
Recent studies have reported associations of retinoid-related orphan receptor alpha () gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders.
Two-hundred and five healthy young Korean adults (female: 98, male: 107; age, 23.0±3.2 years) completed genotyping for the SNP rs11071547, as well as measures for AS and CM. Generalized linear models were used to examine the main and interaction effects of genotype, CM, and sex in determining AS.
The main effect of polymorphisms was not found (=0.760) whereas the main effect of CM and interaction effects among sex, genotype, and maltreatment were significant on AS. In separate analyses by sex, the interaction effect between genotype and maltreatment was significant only in males (＜0.001). In females, the main effects of genotype and CM were significant (both were ＜0.001), in which both a history of CM and C genotype tended to be associated with higher AS.
The association between RORA polymorphism and AS might differ by sex. The interaction between RORA polymorphism and CM was significant only in males whereas genotype and CM independently associated with AS in females. Further studies are encouraged to confirm the relationship between RORA polymorphism and AS.
近期研究报道了维甲酸相关孤儿受体α（RORA）基因单核苷酸多态性（SNP）与抑郁症和焦虑症之间的关联。基于这些研究，我们试图检验RORA多态性是否与焦虑敏感性（AS）相关，AS是抑郁症和焦虑症的中间表型。考虑到基因-环境相互作用以及AS中的性别差异，童年期虐待（CM）和性别被视为混杂因素。
205名健康的韩国年轻成年人（女性98名，男性107名；年龄23.0±3.2岁）完成了RORA SNP rs11071547的基因分型，以及AS和CM的测量。使用广义线性模型来检验RORA基因型、CM和性别在决定AS方面的主效应和交互效应。
未发现RORA多态性的主效应（P = 0.760），而CM的主效应以及性别、基因型和虐待之间的交互效应在AS上具有显著性。按性别进行的单独分析中，RORA基因型与虐待之间的交互效应仅在男性中显著（P＜0.001）。在女性中，基因型和CM的主效应显著（均为P＜0.001），其中CM病史和C基因型均倾向于与较高水平的AS相关。
RORA多态性与AS之间的关联可能因性别而异。RORA多态性与CM之间的交互作用仅在男性中显著，而在女性中，基因型和CM分别独立与AS相关。鼓励进一步研究以证实RORA多态性与AS之间的关系。
