Syracuse University , Syracuse New York 13244, United States.
Environ Sci Technol. 2011 Oct 1;45(19):8151-9. doi: 10.1021/es103712g. Epub 2011 Jun 17.
Perfluorinated chemicals (PFCs) have been used widely in consumer products since the 1950s and are currently found at detectable levels in the blood of humans and animals across the globe. In stark contrast to this widespread exposure to PFCs, there is relatively little research on potential adverse health effects of exposure to these chemicals.
We performed this cross-sectional study to determine if specific blood PFC levels are associated with impaired response inhibition in children.
Blood levels of 11 PFCs were measured in children (N = 83) and 6 PFCs: perfluorooctane sulfonate (PFOS), perfluorohexane sulfate (PFHxS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorooctanesulfonamide (PFOSA), and perfluorodecanoic acid (PFDA) - were found at detectable levels in most children (87.5% or greater had detectable levels). These levels were analyzed in relation to the differential reinforcement of low rates of responding (DRL) task. This task rewards delays between responses (i.e., longer inter-response times; IRTs) and therefore constitutes a measure of response inhibition.
Higher levels of blood PFOS, PFNA, PFDA, PFHxS, and PFOSA were associated with significantly shorter IRTs during the DRL task. The magnitude of these associations was such that IRTs during the task decreased by 29-34% for every 1 SD increase in the corresponding blood PFC.
This study suggests an association between PFC exposure and children's impulsivity. Although intriguing, there is a need for further investigation and replication with a larger sample of children.
全氟化学品（PFCs）自 20 世纪 50 年代以来已广泛应用于消费产品，目前在全球范围内人类和动物的血液中都能检测到这些化学品。与广泛接触 PFCs 形成鲜明对比的是，对这些化学物质暴露的潜在不良健康影响的研究相对较少。
我们进行了这项横断面研究，以确定特定的血液 PFC 水平是否与儿童的反应抑制受损有关。
在 83 名儿童（N=83）的血液中测量了 11 种 PFC 的水平，在大多数儿童（87.5%或以上可检测到水平）中发现了 6 种 PFC：全氟辛烷磺酸（PFOS）、全氟己烷磺酸（PFHxS）、全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟辛烷磺酰胺（PFOSA）和全氟癸酸（PFDA）。这些水平与差异强化低反应率（DRL）任务相关进行了分析。该任务奖励反应之间的延迟（即，更长的反应间时间；IRT），因此构成了对反应抑制的衡量。
血液中 PFOS、PFNA、PFDA、PFHxS 和 PFOSA 水平较高与 DRL 任务中的 IRT 明显缩短有关。这些关联的幅度表明，与对应血液 PFC 每增加 1 个标准差，任务中的 IRT 减少了 29-34%。
这项研究表明 PFC 暴露与儿童的冲动性之间存在关联。尽管这很有趣，但需要进一步研究和复制，以增加儿童的样本量。
