子宫自然杀伤细胞：是时候重新评估了？
Uterine natural killer cells: Time for a re-appraisal?
作者信息
Bulmer Judith N, Lash Gendie E
机构信息
Institute of Cellular Medicine, Newcastle University, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, Guangdong, 510623, China.
出版信息
F1000Res. 2019 Jul 2;8. doi: 10.12688/f1000research.19132.1. eCollection 2019.
Abstract
The presence of unusual natural killer cells in human endometrium has been recognized for 30 years, but despite considerable research effort, the role of uterine natural killer (uNK) cells in both normal and pathological pregnancy remains uncertain. uNK cells may differentiate from precursors present in endometrium, but migration from peripheral blood in response to chemokine stimuli with modification to a uNK cell phenotype is also possible. uNK cells produce a wide range of secretory products with diverse effects on trophoblast and spiral arteries which may play an important role in implantation and early placentation. Interactions with other decidual cell populations are also becoming clear. Recent evidence has demonstrated subpopulations of uNK cells and the presence of other innate lymphoid cell populations in decidua which may refine future approaches to investigation of the role of uNK cells in human pregnancy.
摘要
人类子宫内膜中存在异常自然杀伤细胞已被认识30年了，但尽管进行了大量研究，子宫自然杀伤（uNK）细胞在正常和病理妊娠中的作用仍不确定。uNK细胞可能由子宫内膜中的前体细胞分化而来，但也有可能是外周血中的细胞在趋化因子刺激下迁移过来，并转变为uNK细胞表型。uNK细胞产生多种分泌产物，对滋养层细胞和螺旋动脉有不同影响，这可能在着床和早期胎盘形成中起重要作用。与其他蜕膜细胞群体的相互作用也逐渐明晰。最近的证据表明，uNK细胞存在亚群，蜕膜中还存在其他先天淋巴细胞群体，这可能会改进未来研究uNK细胞在人类妊娠中作用的方法。
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