Laboratory of Clinical Virology, Rega Institute for Medical Research, Leuven, Belgium.
Clin Microbiol Infect. 2011 Jun;17(6):947-9. doi: 10.1111/j.1469-0691.2010.03374.x. Epub 2010 Nov 5.
Recently, we proposed a new classification for 'subgenotype A' of hepatitis B virus (HBV), in which the novel 'quasi-subgenotype A3' group comprising HBV 'subgenotype A3', 'tentative A4', and A5 was introduced. Newly 'Tentative subgenotype A7' strains from Cameroon were introduced by Hubschen et al. However, our meticulous phylogenetic analysis demonstrated that these isolates should also be classified into 'quasi-subgenotype A3'. Such misclassification can be avoided by following established principles for HBV subgenotyping. Moreover, their close evolutionary relationship with A3 highlights our hypothesis that geographical origin may be an important factor in further classification of HBV subgenotypes.
最近，我们提出了一种新的乙型肝炎病毒 (HBV)“亚基因型 A”分类方法，其中包括 HBV“亚基因型 A3”、“暂定 A4”和 A5的新型“准亚基因型 A3”组。Hubschen 等人介绍了来自喀麦隆的新的“暂定亚基因型 A7”株。然而，我们细致的系统进化分析表明，这些分离株也应归类为“准亚基因型 A3”。通过遵循 HBV 亚基因型分型的既定原则，可以避免这种错误分类。此外，它们与 A3 的密切进化关系支持了我们的假设，即地理起源可能是进一步分类 HBV 亚基因型的一个重要因素。
