miR-200c 在上皮-间充质转化、抗细胞凋亡和乳腺癌干细胞表型的交汇点。
miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype.
出版信息
Breast Cancer Res. 2011 Jun 10;13(3):110. doi: 10.1186/bcr2885.
Abstract
Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics.
摘要
miR-200 家族的 miRNA 表达降低与乳腺癌细胞的生长和转移有关。在这个家族中，miR-200c 因其能够靶向上皮-间充质转化的调节因子 ZEB1 和 ZEB2 而备受关注。上一期的《乳腺癌研究》杂志上的一篇文章确定了 miR-200c 的其他靶标，这些靶标与增加癌细胞侵袭性、抗细胞凋亡以及诱导乳腺癌干细胞特性有关。
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1
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2
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Oncogene. 2011 Sep 1;30(35):3735-44. doi: 10.1038/onc.2011.96. Epub 2011 Apr 11.
3
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Mol Cell. 2010 Sep 10;39(5):761-72. doi: 10.1016/j.molcel.2010.08.013.
4
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EMBO Rep. 2010 Sep;11(9):670-7. doi: 10.1038/embor.2010.117. Epub 2010 Aug 13.
5
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Mol Cell. 2010 Jun 25;38(6):908-15. doi: 10.1016/j.molcel.2010.05.018.
6
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J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):213-23. doi: 10.1007/s10911-010-9183-z. Epub 2010 May 25.
7
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8
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Breast Cancer Res. 2010;12(2):201. doi: 10.1186/bcr2484. Epub 2010 Mar 19.
9
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J Oncol. 2010;2010:821717. doi: 10.1155/2010/821717. Epub 2009 Dec 15.
10
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.EMT激活因子ZEB1通过抑制抑制干性的微小RNA来促进肿瘤发生。
Nat Cell Biol. 2009 Dec;11(12):1487-95. doi: 10.1038/ncb1998. Epub 2009 Nov 22.
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