Cruz J R, Cáceres P, Cano F, Flores J, Bartlett A, Torún B
Program on Infection Nutrition and Immunology, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.
J Clin Microbiol. 1990 Aug;28(8):1780-4. doi: 10.1128/jcm.28.8.1780-1784.1990.
From March 1987 to February 1988, fecal excretion of adenovirus types 40 and 41 and rotavirus serotypes in 194 children (age, 0 to 3 years) from a rural community of Guatemala was monitored. In total, 458 samples taken during 385 episodes of diarrhea and 191 specimens obtained during symptom-free periods were examined by enzyme-linked immunosorbent assay. Fifty-seven children hospitalized because of diarrhea were also studied. Among the rural children, 43 (22.2%) excreted adenovirus types 40 and 41 and 20 (10.3%) shed rotaviruses. Adenovirus types 40 and 41 were associated with 54 (14.0%) illnesses, and rotaviruses were associated with 18 (4.7%) illnesses. Asymptomatic infections with adenovirus types 40 and 41 were documented in nine children and with rotaviruses in two children. Fifteen typeable rotaviruses were identified as serotype 2. In the hospital population, 36 (63.2%) children had viral infections. Rotaviruses were identified in 29 (50.9%) and adenovirus types 40 and 41 were identified in 15 (31.2%) of 48 subjects tested. Dual infections by these viruses were found in eight children. Of 22 typeable strains of rotaviruses, 9 (34.6%) were serotype 1, 12 (46.1%) were serotype 2, and 1 (3.8%) was serotype 3. All the children infected with serotype 2 rotavirus were coinfected with other enteric pathogens, while only three (37.5%) of those infected with rotavirus serotype 1 excreted another pathogen. Adenovirus types 40 and 41 are an important cause of gastroenteritis in both ambulatory and hospitalized Guatemalan children. There seems to be a difference in the pathogenicity among rotavirus serotypes.
1987年3月至1988年2月，对危地马拉一个农村社区的194名儿童（年龄0至3岁）的腺病毒40型和41型粪便排泄情况以及轮状病毒血清型进行了监测。总共对腹泻385次期间采集的458份样本以及无症状期采集的191份标本进行了酶联免疫吸附测定。还对57名因腹泻住院的儿童进行了研究。在农村儿童中，43名（22.2%）排泄腺病毒40型和41型，20名（10.3%）排泄轮状病毒。腺病毒40型和41型与54例（14.0%）疾病有关，轮状病毒与18例（4.7%）疾病有关。记录到9名儿童无症状感染腺病毒40型和41型，2名儿童无症状感染轮状病毒。15株可分型的轮状病毒被鉴定为血清型2。在住院儿童中，36名（63.2%）儿童有病毒感染。在48名接受检测的儿童中，29名（50.9%）检测出轮状病毒，15名（31.2%）检测出腺病毒40型和41型。在8名儿童中发现了这些病毒的双重感染。在22株可分型的轮状病毒菌株中，9株（34.6%）为血清型1，12株（46.1%）为血清型2，1株（3.8%）为血清型3。所有感染血清型2轮状病毒的儿童均同时感染了其他肠道病原体，而感染血清型1轮状病毒的儿童中只有3名（37.5%）排泄了另一种病原体。腺病毒40型和41型是危地马拉门诊和住院儿童肠胃炎的重要病因。不同轮状病毒血清型的致病性似乎存在差异。
