Department of Medicine, McGill University, Montreal, Canada.
Environ Res. 2011 Aug;111(6):853-60. doi: 10.1016/j.envres.2011.05.022.
The purpose of this study was to determine whether short-term changes in ambient temperature were associated with daily mortality among persons who lived in Montreal, Canada, and who died in the urban area between 1984 and 2007. We made use of newly developed distributed lag non-linear Poisson models, constrained to a 30 day lag period, and we adjusted for temporal trends and nitrogen dioxide and ozone. We found a strong non-linear association with high daily maximum temperatures showing an apparent threshold at about 27°C; this association persisted until about lag 5 days. For example, we found across all lag periods that daily non-accidental mortality increased by 28.4% (95% confidence interval: 13.8-44.9%) when temperatures increased from 22.5 to 31.8°C (75-99th percentiles). This association was essentially invariant to different smoothers for time. Cold temperatures were not found to be associated with daily mortality over 30 days, although there was some evidence of a modest increased risk from 2 to 5 days. The adverse association with colder temperatures was sensitive to the smoother for time. For cardio-respiratory mortality we found increased risks for higher temperatures of a similar magnitude to that of non-accidental mortality but no effects at cold temperatures.
本研究旨在确定加拿大蒙特利尔市城区内 1984 年至 2007 年期间死亡的人群,其环境温度的短期变化是否与每日死亡率有关。我们利用新开发的分布式滞后非线性泊松模型,将滞后时间限制在 30 天内,并进行了时间趋势、二氧化氮和臭氧的调整。我们发现,高温与高每日最高温度之间存在强烈的非线性关联,在约 27°C 处存在明显的阈值;这种关联一直持续到大约滞后 5 天。例如,我们发现在所有滞后期内,当温度从 22.5°C 升高到 31.8°C(75-99 百分位数)时,每日非意外死亡率增加了 28.4%(95%置信区间:13.8-44.9%)。这种关联在不同的时间平滑器下基本不变。在 30 天以上的时间内,低温与每日死亡率之间没有关联,但有一些证据表明,在 2 至 5 天之间,风险略有增加。与低温的不利关联对时间平滑器敏感。对于心肺死亡率,我们发现高温的风险增加与非意外死亡率的幅度相似,但低温没有影响。