National Institute of Public Health Surveillance (InVS), Saint Maurice, France.
Environ Res. 2011 Aug;111(6):761-4. doi: 10.1016/j.envres.2011.05.018.
Exposure to phthalates and Bisphenol A could cause developmental and reproductive toxicity. This study provides a first assessment of these exposures for more than 250 French pregnant women. The median concentrations of total and free Bisphenol A in urine were similar to those in other studies except the highest concentrations (5% of women had total and free Bisphenol A >50μg/L). Our study highlights high levels of Di-(2-ethylhexyl)-phthalate metabolites in pregnant women, suggesting recent exposure, probably in hospital. Differences between types of delivery (caesarean vs. natural) support this hypothesis. This is a significant implication for large-scale biomonitoring studies among this population.
接触邻苯二甲酸酯和双酚 A 可能会导致发育和生殖毒性。本研究首次评估了 250 多名法国孕妇的这些接触情况。尿液中总 Bisphenol A 和游离 Bisphenol A 的中位数浓度与其他研究相似，但最高浓度（5%的女性总 Bisphenol A 和游离 Bisphenol A ＞50μg/L）除外。我们的研究强调了孕妇中二-(2-乙基己基)邻苯二甲酸酯代谢物的高水平，表明近期暴露，可能发生在医院。不同类型的分娩（剖宫产与自然分娩）支持这一假设。这对该人群的大规模生物监测研究具有重要意义。
