Department of Surgery, The Chinese University of Hong Kong, North District Hospital, Hong Kong Special Administrative Region, Shatin, New Territories, Hong Kong.
J Urol. 2011 Aug;186(2):610-4. doi: 10.1016/j.juro.2011.03.108.
We identified the profile of lower urinary tract changes in ketamine users in the community. In addition, we identified the relative risks of dose, frequency of ingestion and duration of ketamine use for changes in lower urinary tract function.
A mobile medical assessment service was established at specific youth centers, and subjects who were known to social workers and who had a history of ketamine use were invited to participate in health screening. Lower urinary tract function was evaluated using the Pelvic Pain, Urgency and Frequency questionnaire, and uroflowmetry and ultrasonography.
Use of ketamine more than 3 times weekly was significantly associated with lower voided volumes. Pelvic Pain, Urgency and Frequency questionnaire scores were significantly higher for ketamine use for more than 24 months compared to use for short durations (7.82 vs 6.00). The scores on the symptom and bother subscales of the Pelvic Pain, Urgency and Frequency questionnaire decreased progressively with increased duration of abstinence. For individuals after 1 year of abstinence the Pelvic Pain, Urgency and Frequency questionnaire scores were significantly lower and voided volumes were higher than those for active users.
Ketamine users with at least a 2-year habit of 3 or more hits per week have altered bladder function that can be recognized and that causes bother. These early functional changes have the potential to normalize after 1 year of ketamine abstinence. This study provides a basis for the development of health promotion material that can be used in the community by welfare workers seeking to encourage drug cessation.
我们确定了社区中氯胺酮使用者下尿路变化的特征。此外，我们还确定了剂量、摄入频率和氯胺酮使用时间与下尿路功能变化的相对风险。
在特定的青年中心设立了移动医疗评估服务，邀请社会工作者认识并曾有过氯胺酮使用史的人参加健康筛查。使用盆腔疼痛、急迫和频数问卷以及尿流率和超声检查评估下尿路功能。
每周使用氯胺酮超过 3 次与较低的排尿量显著相关。与短期使用（7.82 分比 6.00 分）相比，使用氯胺酮超过 24 个月的盆腔疼痛、急迫和频数问卷评分显著更高。盆腔疼痛、急迫和频数问卷的症状和困扰子量表评分随禁欲时间的增加而逐渐降低。对于禁欲 1 年以上的个体，盆腔疼痛、急迫和频数问卷评分显著降低，排尿量也高于活跃使用者。
至少有 2 年每周使用 3 次或以上习惯的氯胺酮使用者膀胱功能发生改变，这种改变可被识别并引起困扰。这些早期的功能变化在 1 年的氯胺酮禁欲后有恢复正常的可能。本研究为开发社区福利工作者可用于鼓励戒毒的健康促进材料提供了依据。
