Division of Urology, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
J Urol. 2011 Aug;186(2):556-62. doi: 10.1016/j.juro.2011.03.109.
Although shock wave lithotripsy is dependent on patient and stone related factors, there are few reliable algorithms predictive of its success. In this study we develop a comprehensive nomogram to predict renal and ureteral stone shock wave lithotripsy outcomes.
During a 5-year period data from patients treated at our lithotripsy unit were reviewed. Analysis was restricted to patients with a solitary renal or ureteral calculus 20 mm or less. Demographic, stone, patient, treatment and 3-month followup data were collected from a prospective database. All patients were treated using the Philips Lithotron® lithotripter.
A total of 422 patients (69.7% male) were analyzed. Mean stone size was 52.3±39.3 mm2 for ureteral stones and 78.9±77.3 mm2 for renal stones, with 95 (43.6%) of the renal stones located in the lower pole. The single treatment success rates for ureteral and renal stones were 60.3% and 70.2%, respectively. On univariate analysis predictors of shock wave lithotripsy success, regardless of stone location, were age (p=0.01), body mass index (p=0.01), stone size (p<0.01), mean stone density (p<0.01) and skin to stone distance (p<0.01). By multivariate logistic regression for renal calculi, age, stone area and skin to stone distance were significant predictors with an AUC of 0.75. For ureteral calculi predictive factors included body mass index and stone size (AUC 0.70).
Patient and stone parameters have been identified to create a nomogram that predicts shock wave lithotripsy outcomes using the Lithotron lithotripter, which can facilitate optimal treatment based decisions and provide patients with more accurate single treatment success rates for shock wave lithotripsy tailored to patient specific situations.
尽管体外冲击波碎石术取决于患者和结石相关因素,但目前尚无可靠的算法能准确预测其疗效。本研究旨在建立一种全面的列线图,以预测肾结石和输尿管结石行体外冲击波碎石术的疗效。
回顾性分析了我们碎石中心 5 年内接受治疗的患者数据。本研究仅纳入结石长径<20mm 的单侧肾结石或输尿管结石患者。从前瞻性数据库中收集患者的人口统计学、结石、患者、治疗和 3 个月随访数据。所有患者均采用飞利浦 Lithotron®碎石机进行治疗。
共纳入 422 例(69.7%为男性)患者。输尿管结石的平均结石大小为 52.3±39.3mm²,肾结石为 78.9±77.3mm²,95 例(43.6%)肾结石位于下极。输尿管结石和肾结石单次治疗成功率分别为 60.3%和 70.2%。单因素分析结果显示,无论结石位置如何,年龄(p=0.01)、体质指数(p=0.01)、结石大小(p<0.01)、平均结石密度(p<0.01)和皮肤至结石距离(p<0.01)均为体外冲击波碎石术成功的预测因素。多因素 logistic 回归分析结果显示,肾结石的独立预测因素为年龄、结石面积和皮肤至结石距离,其 AUC 为 0.75。对于输尿管结石,预测因素包括体质指数和结石大小(AUC 为 0.70)。
本研究确定了患者和结石参数,建立了一个列线图,可使用 Lithotron 碎石机预测体外冲击波碎石术的疗效,有助于根据患者具体情况做出最佳治疗决策,并为患者提供更准确的针对特定个体情况的单次碎石成功率。