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古菌光趋性中的跨膜信号转导:通过电子顺磁共振波谱学研究的感觉视紫红质 II 转导复合物。

Transmembrane signal transduction in archaeal phototaxis: the sensory rhodopsin II-transducer complex studied by electron paramagnetic resonance spectroscopy.

机构信息

Faculty of Physics, University of Osnabrück, Barbarastrasse 7, 49076 Osnabrück, Germany.

出版信息

Eur J Cell Biol. 2011 Sep;90(9):731-9. doi: 10.1016/j.ejcb.2011.04.013.

Abstract

Archaeal photoreceptors, together with their cognate transducer proteins, mediate phototaxis by regulating cell motility through two-component signal transduction pathways. This sensory pathway is closely related to the bacterial chemotactic system, which has been studied in detail during the past 40 years. Structural and functional studies applying site-directed spin labelling and electron paramagnetic resonance spectroscopy on the sensory rhodopsin II/transducer (NpSRII/NpHtrII) complex of Natronomonas pharaonis have yielded insights into the structure, the mechanisms of signal perception, the signal transduction across the membrane and provided information about the subsequent information transfer within the transducer protein towards the components of the intracellular signalling pathway. Here, we provide an overview about the findings of the last decade, which, combined with the wealth of data from research on the Escherichia coli chemotaxis system, served to understand the basic principles microorganisms use to adapt to their environment. We document the time course of a signal being perceived at the membrane, transferred across the membrane and, for the first time, how this signal modulates the dynamic properties of a HAMP domain, a ubiquitous signal transduction module found in various protein classes.

摘要

古菌光感受器与其相应的转导蛋白一起,通过双组分信号转导途径调节细胞运动来介导趋光性。这个感觉途径与细菌趋化系统密切相关,在过去的 40 年中,该系统已经得到了详细的研究。应用定点旋转标记和电子顺磁共振波谱学对嗜盐古菌的感觉视紫红质 II/转导蛋白(NpSRII/NpHtrII)复合物的结构和功能研究,深入了解了信号感知的结构、机制、跨膜信号转导,并提供了关于转导蛋白内的后续信息传递的信息,朝向细胞内信号通路的组成部分。在这里,我们提供了过去十年的研究结果概述,这些结果结合了来自大肠杆菌趋化系统研究的大量数据,有助于理解微生物用来适应其环境的基本原理。我们记录了在膜上感知信号、跨膜传递信号的时间过程,并且首次展示了这种信号如何调节在各种蛋白质类中发现的普遍存在的信号转导模块 HAMP 域的动态特性。

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