Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy.
Colloids Surf B Biointerfaces. 2011 Oct 15;87(2):333-9. doi: 10.1016/j.colsurfb.2011.05.041. Epub 2011 May 27.
The development of advanced biomaterials and drug-delivery systems has had a significant impact on our ability to treat several diseases. A new study was performed on niosomal formulations obtained from a mixture of commercial surfactants (Tween 80 and Span 80) to be applied topically for the release of Capsaicin. Capsaicin is the pungent principle of red pepper and it has a variety of pharmacological actions on the cardiovascular, respiratory and nervous systems. Niosomal carriers were prepared using a particular ratio between surfactants, to obtain systems with a specific HLB (10,12,14) and characterized in terms of dimension, morphology and their drug entrapment efficiency. Niosomes were compared to microemulsions prepared from the same surfactants in the same ratio, to evaluate their possible use in transdermal drug delivery. As regards the in vitro percutaneous permeation of Capsaicin from both microemulsions and niosomal formulations, it was carried out using diffusion Franz cells. The results indicate that niosomes could better promote the transdermal delivery of Capsaicin, with respect to microemulsions, even if both carriers could be an effective vehicle for topical delivery of this drug.
先进生物材料和药物输送系统的发展极大地提高了我们治疗多种疾病的能力。一项新的研究是关于从商业表面活性剂（吐温 80 和司盘 80）混合物中获得的类脂囊泡制剂，旨在通过局部给药释放辣椒素。辣椒素是红辣椒的刺激性成分，它对心血管、呼吸和神经系统具有多种药理学作用。使用特定的表面活性剂比例制备了类脂囊泡载体，以获得具有特定 HLB（10、12、14）的系统，并根据尺寸、形态及其药物包封效率进行了表征。将类脂囊泡与相同比例的相同表面活性剂制备的微乳液进行了比较，以评估它们在经皮药物传递中的可能用途。关于辣椒素从微乳液和类脂囊泡制剂的体外经皮渗透，使用扩散 Franz 细胞进行了研究。结果表明，与微乳液相比，类脂囊泡可以更好地促进辣椒素的经皮传递，尽管这两种载体都可以作为该药物局部递送的有效载体。
