Ghumman Shazia Akram, Ijaz Amna, Noreen Sobia, Aslam Afeefa, Kausar Rizwana, Irfan Ali, Latif Sumera, Shazly Gamal A, Shah Pervaiz Akhtar, Rana Maria, Aslam Asma, Altaf Momina, Kotwica-Mojzych Katarzyna, Bin Jardan Yousef A
College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
Pharmaceuticals (Basel). 2023 Oct 3;16(10):1406. doi: 10.3390/ph16101406.
Curcumin's applications in the treatment of conditions including osteoarthritis, dementia, malignancies of the pancreas, and malignancies of the intestines have drawn increasing attention. It has several wonderful qualities, including being an anti-inflammatory agent, an anti-mutagenic agent, and an antioxidant, and has substantially reduced inherent cytotoxicity outcomes. Although curcumin possesses multiple known curative properties, due to its limited bioavailability, it is necessary to develop efficient strategies to overcome these hurdles. To establish an effective administration method, various niosomal formulations were optimized using the Box-Behnken design and assessed in the current investigation. To examine the curcumin niosomes, zeta sizer, zeta potential, entrapment efficiency, SEM, antioxidant potential, cytotoxicity, and release studies were performed. The optimized curcumin niosomes exhibited an average particle size of 169.4 nm, a low PDI of 0.189, and high entrapment efficiency of 85.4%. The release profile showed 79.39% curcumin after 24 h and had significantly higher antioxidant potential as compared with that of free curcumin. The cytotoxicity results of curcumin niosomes presented increased mortality in human ovarian cancer A2780.
姜黄素在骨关节炎、痴呆症、胰腺癌和肠癌等病症治疗中的应用已引起越来越多的关注。它具有多种出色特性，包括作为抗炎剂、抗诱变剂和抗氧化剂，且已大幅降低内在细胞毒性结果。尽管姜黄素具有多种已知的治疗特性，但由于其生物利用度有限，有必要制定有效的策略来克服这些障碍。为建立有效的给药方法，在本研究中使用Box-Behnken设计优化了各种非离子型脂质体制剂并进行评估。为检测姜黄素脂质体，进行了zeta粒度分析仪、zeta电位、包封率、扫描电子显微镜、抗氧化潜力、细胞毒性和释放研究。优化后的姜黄素脂质体平均粒径为169.4 nm，低多分散指数为0.189，高包封率为85.4%。释放曲线显示24小时后姜黄素释放率为79.39%，与游离姜黄素相比具有显著更高的抗氧化潜力。姜黄素脂质体的细胞毒性结果显示人卵巢癌A2780的死亡率增加。
