Department of Anatomy and Molecular Embryology, Ruhr University, Bochum, Germany.
Ann Anat. 2011 Oct 20;193(5):453-8. doi: 10.1016/j.aanat.2011.05.004. Epub 2011 May 27.
Hyperostosis frontalis interna is a morphological pattern characterized by single or multiple bony nodules situated on the inner lamina of the frontal bone. It is seldom found in males, but it is a common phenomenon among post-menopausal females in modern societies but relatively rare in antiquity. The etiopathogenesis of the trait is a matter of debate and ranges from genetic predisposition to epigenetic, while endocrine disturbances, aging, and dietary factors are also listed among the causes. We studied the frequency, characteristic features, and etiopathogenesis of the disease in recent cadaveric and dry skull specimens. The frequency of hyperostosis frontalis interna in cadavers and dry skull materials was almost identical, 12.5% and 12.3%, respectively. In cadavers, 87.5% of severe hyperostosis frontalis interna cases were found in females over 65 years-old. Interestingly, in two cadavers we found hyperostotic lesions spreading onto adjacent tissues such as the dura and falx cerebri. We provide some new aspects that may help in better understanding of the etiopathogenesis of hyperostosis frontalis interna. Thereby, we discuss the various etiopathogenesis models found in the literature.
颅内骨肥厚是一种形态学模式，其特征是单个或多个骨结节位于额骨内板。它在男性中很少见，但在现代社会中绝经后的女性中很常见，但在古代相对较少。该特征的病因学是一个有争议的问题，范围从遗传易感性到表观遗传，而内分泌紊乱、衰老和饮食因素也被列为病因。我们研究了最近的尸体和干颅骨标本中该疾病的频率、特征和病因学。在尸体和干颅骨标本中，颅内骨肥厚的发生率几乎相同，分别为 12.5%和 12.3%。在尸体中，87.5%的严重颅内骨肥厚病例发生在 65 岁以上的女性中。有趣的是，在两具尸体中，我们发现了骨质增生病变扩散到邻近组织，如硬脑膜和大脑镰。我们提供了一些可能有助于更好地理解颅内骨肥厚病因学的新方面。因此，我们讨论了文献中发现的各种病因学模型。
