Eudistomidins H-K，来自冲绳海洋被囊动物 Eudistoma glaucus 的新型 β-咔啉生物碱。

Eudistomidins H-K, new β-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus.

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4220-3. doi: 10.1016/j.bmcl.2011.05.072. Epub 2011 May 30.

DOI:10.1016/j.bmcl.2011.05.072

Abstract

Four new β-carboline alkaloids, eudistomidins H-K (1-4), were isolated from an Okinawan marine tunicate Eudistoma glaucus and the structures of 1-4 were elucidated on the basis of spectroscopic data. Eudistomidins H (1) and I (2) were new β-carboline alkaloids possessing a unique fused-tetracyclic ring system consisting of a tetrahydro β-carboline ring and a hexahydropyrimidine ring. Eudistomidin J (3) showed relatively potent cytotoxicity against murine leukemia cells P388 and L1210, and human epidermoid carcinoma cells KB in vitro.

摘要

从冲绳海洋被囊动物 Eudistoma glaucus 中分离得到四个新的β-咔啉生物碱，eudistomidins H-K（1-4），并根据光谱数据阐明了 1-4 的结构。eudistomidins H（1）和 I（2）是新的β-咔啉生物碱，具有独特的稠合四环体系，由四氢β-咔啉环和六氢嘧啶环组成。eudistomidin J（3）在体外对小鼠白血病细胞 P388 和 L1210 以及人表皮样癌细胞 KB 表现出相对较强的细胞毒性。