Chow Dominic C, Wood Robert, Choi Julia, Grandinetti Andrew, Gerschenson Mariana, Sriratanaviriyakul Narin, Nakamoto Beau, Shikuma Cecilia, Low Phillip
Hawaii Center for AIDS, Department of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA.
HIV Clin Trials. 2011 May-Jun;12(3):141-50. doi: 10.1310/hct1203-141.
HIV infection has been implicated in dysregulation of the autonomic nervous system.
Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV.
57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups.
There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
人类免疫缺陷病毒（HIV）感染与自主神经系统功能失调有关。
横断面研究，通过心率变异性（HRV）测量来检测持续可检测到的HIV病毒载量与自主神经功能之间的关系。非病毒学抑制（NVS）定义为在自主神经功能测试前至少3个月病毒载量可检测到。在以下4种操作过程中测量HRV：静息和定频呼吸以及持续握力和倾斜试验。通过分析HRV的时域和频域来确定副交感神经和交感神经调节情况。
57名参与者被纳入3组：22名是HIV病毒学抑制（VS；HIV病毒载量不可检测）的HIV感染参与者，9名是有NVS的HIV感染参与者，26名是HIV血清学阴性对照者。与对照组相比，整个HIV感染组的时域参数较低。HIV感染参与者之间的时域参数无显著差异。在任何操作过程中，对照组与所有HIV感染参与者之间、NVS组与VS组之间的频域参数均无差异。
HIV感染个体与HIV血清学阴性对照者之间存在自主神经功能差异，但NVS组与VS组之间不存在差异。
