儿童单纯疱疹严重神经系统疾病：发病率和长期结局。
Herpes simplex serious neurological disease in young children: incidence and long-term outcome.
机构信息
Division of Infection and Immunity, Centre for Virology (UCL Campus), Windeyer Institute of Medical Sciences, University College Medical School, 46 Cleveland Street, London W1T 4JF, UK.
出版信息
Arch Dis Child. 2012 Feb;97(2):162-5. doi: 10.1136/adc.2010.204677. Epub 2011 Jun 17.
Abstract
OBJECTIVE
To determine the contribution of herpes simplex virus (HSV) to serious neurological disease.
SETTING AND PATIENTS
A 3-year prospective survey of children aged 2-23 months in Britain and Ireland.
RESULTS
19 children had HSV central nervous system (CNS) infection; 13 aged 2-11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12-35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2-11 months and 4.5% in older children.
CONCLUSIONS
The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy.
摘要
目的
确定单纯疱疹病毒（HSV）对严重神经系统疾病的影响。
设置和患者
英国和爱尔兰 2-23 个月大的儿童进行了为期 3 年的前瞻性调查。
结果
19 名儿童患有单纯疱疹病毒中枢神经系统（CNS）感染；13 名 2-11 个月大的儿童有局灶性神经影像学异常，11 名有长期神经后遗症。在 6 名 12-35 个月大的儿童中，1 名有异常神经影像学表现，3 名有长期神经后遗症。19 名儿童中有 17 名患有严重神经系统疾病。单纯疱疹病毒中枢神经系统感染导致 2-11 个月大儿童严重神经系统疾病的发病率为 1/64000/年，较大儿童为 1/230000。HSV 中枢神经系统感染的临床表现从脑炎到伴有发热和抽搐的严重疾病，再到缺乏脑病的较轻疾病不等。
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