Fine A, Meldrum B S, Patel S
Department of Physiology, Dalhousie University School of Medicine, Halifax, Nova Scotia, Canada.
Neuropsychologia. 1990;28(6):627-34. doi: 10.1016/0028-3932(90)90038-p.
Systemic administration of pilocarpine to rats induces seizures that resemble complex partial epilepsy in humans. Susceptibility to these seizures is increased by lesion of the GABAergic striatonigral projection. Transplantation of fetal GABAergic neurons, but also of control non-GABAergic tissue, to the deafferent substantia nigra can reduce such lesion-increased seizure susceptibility. These observations are consistent with prior evidence that GABAergic basal ganglia outflow plays an important role in controlling the spread of seizures, and raise the possibility that intracerebral grafts may be of use for therapy of medically-unresponsive epilepsies.
对大鼠进行毛果芸香碱的全身给药会诱发类似于人类复杂部分性癫痫的癫痫发作。GABA能纹状体黑质投射受损会增加对这些癫痫发作的易感性。将胎儿GABA能神经元以及对照非GABA能组织移植到去传入的黑质中，可以降低这种损伤增加的癫痫易感性。这些观察结果与先前的证据一致，即GABA能基底神经节流出在控制癫痫发作的传播中起重要作用，并提出了脑内移植可能用于治疗药物难治性癫痫的可能性。
