Visioncare Research Ltd., Craven House, West Street, Farnham, Surrey GU97EN, UK.
Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6801-6. doi: 10.1167/iovs.11-7177.
To evaluate the influence of peripheral ocular topography, as evaluated by optical coherence tomography (OCT), compared with traditional measures of corneal profile using keratometry and videokeratoscopy, on soft contact lens fit.
Ocular surface topography was analyzed in 50 subjects aged 22.8 years (SD ±5.0) using videokeratoscopy (central keratometry, corneal height, and shape factor) and OCT to give both full sagittal cross-sections of the cornea and cross-sections of the corneoscleral junctions. Corneoscleral junction angle, corneal diameter, corneal sagittal height, and scleral radius were analyzed from the images. Horizontal visible iris diameter and vertical palpebral aperture were analyzed from digital slit lamp images. Lens fit was graded after 30 minutes wear of a -2.50 D commercially available standard hydrogel (etafilcon A, modulus 0.30 MPa) and silicone hydrogel (galyfilcon A, 0.43 MPa) design of similar geometries (8.30-mm base curve, 14.0-mm diameter).
The mean horizontal corneal diameter was 13.39 mm (SD ±0.44). In many cases, there was a tangential transition at the corneoscleral junction. The corneoscleral shape profile analyzed from cross-sectional OCT images contributed significantly (P < 0.001) to the prediction of soft contact lens fit compared with keratometry and videokeratoscopy, accounting for up to 24% of the variance in lens movement. The fit of the stiffer material silicone hydrogel lens was better able to be predicted and was more varied than the hydrogel contact lens.
The extra peripheral corneoscleral data gained from OCT characterization of ocular surface architecture provide valuable insight into soft contact lens fit dynamics.
评估通过光学相干断层扫描(OCT)评估的周边眼部地形学与角膜曲率计和角膜地形图仪评估的传统角膜形态学测量值对软性隐形眼镜适配的影响。
使用角膜地形图仪(中央角膜曲率、角膜高度和形状因子)和 OCT 对 50 名年龄为 22.8 岁(标准差±5.0)的受试者的眼表面地形进行分析,以提供角膜的全矢状横截面和角膜巩膜交界处的横截面。从图像中分析了巩膜角膜结合角、角膜直径、角膜矢状高度和巩膜半径。从数字裂隙灯图像中分析水平可见虹膜直径和垂直睑裂。在佩戴 30 分钟后,评估了具有相似几何形状(基弧 8.30mm,直径 14.0mm)的商业现成标准水凝胶(etafilcon A,模量 0.30MPa)和硅水凝胶(galyfilcon A,0.43MPa)设计的软性隐形眼镜适配情况。
平均水平角膜直径为 13.39mm(标准差±0.44)。在许多情况下,角膜巩膜交界处存在切线过渡。与角膜曲率计和角膜地形图仪相比,从横截面 OCT 图像分析的巩膜角膜形状轮廓对软性隐形眼镜适配的预测有显著贡献(P<0.001),占镜片运动变化的 24%。更硬的硅水凝胶隐形眼镜的适配情况能够更好地预测,并且变化更大。
通过对眼部表面结构的 OCT 特征描述获得的周边额外的角膜巩膜数据为软性隐形眼镜适配动力学提供了有价值的见解。