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基于无伪影的巩膜不对称性的 topography。

Artefact-free topography based scleral-asymmetry.

机构信息

School of Engineering, University of Liverpool, Liverpool, United Kingdom.

Federal University of São Paulo, São Paulo, Brazil.

出版信息

PLoS One. 2019 Jul 26;14(7):e0219789. doi: 10.1371/journal.pone.0219789. eCollection 2019.

Abstract

PURPOSE

To present a three-dimensional non-parametric method for detecting scleral asymmetry using corneoscleral topography data that are free of edge-effect artefacts.

METHODS

The study included 88 participants aged 23 to 65 years (37.7±9.7), 47 women and 41 men. The eye topography data were exported from the Eye Surface Profiler software in MATLAB binary data container format then processed by custom built MATLAB codes entirely independent from the profiler software. Scleral asymmetry was determined initially from the unprocessed topography before being determined again after removing the edge-effect noise. Topography data were levelled around the limbus, then edge-effect was eliminated using a robust statistical moving median technique. In addition to comparing raw elevation data, scleral elevation was also compared through fitting a sphere to every single scleral surface and determining the relative elevation from the best-fit sphere reference surface.

RESULTS

When considering the averaged raw topography elevation data in the scleral section of the eye at radius 8 mm, the average raw elevations of the right eyes' sclera were -1.5±1.77, -1.87±2.12, -1.36±1.82 and -1.57±1.87 mm. In the left eyes at the same radius the average raw elevations were -1.62±1.78, -1.82±2.07, -1.28±1.76 and -1.68±1.93 mm. While, when considering the average raw elevation of the sclera after removing the edge effect, the average raw elevations of the right eyes were -3.71±0.25, -4.06±0.23, -3.95±0.19 and -3.95±0.23 mm. In the left eyes at the same radius the average raw elevations were -3.71±0.19, -3.97±0.22, -3.96±0.19 and -3.96±0.18 mm in the nasal, temporal, superior and inferior sides respectively. Maximum raw elevation asymmetry in the averaged scleral raw elevation was 1.6647±0.9015 mm in right eyes and 1.0358±0.6842 mm in left eyes, both detected at -38° to the nasal side. Best-fit sphere-based relative elevation showed that sclera is more elevated in three main meridians at angles -40°, 76°, and 170° in right eyes and -40°, 76°, and 170° in left eyes, all measured from the nasal meridian. Maximum recorded relative elevation asymmetries were 0.0844±0.0355 mm and 0.068±0.0607 mm at angular positions 76° and 63.5° for right and left eyes in turn.

CONCLUSIONS

It is not possible to use corneoscleral topography data to predict the scleral shape without considering a method of removing the edge-effect from the topography data. The nasal side of the sclera is higher than the temporal side, therefore, rotationally symmetric scleral contact lenses are more likely to be translated towards the temporal side. The scleral shape is best described by levelled raw elevation rather than relative elevation.

摘要

目的

介绍一种使用无边缘效应伪影的角膜巩膜地形图数据检测巩膜不对称的三维非参数方法。

方法

该研究纳入了 88 名年龄在 23 至 65 岁之间(37.7±9.7)的参与者,其中包括 47 名女性和 41 名男性。眼地形数据从 Eye Surface Profiler 软件以 MATLAB 二进制数据容器格式导出,然后由自定义的 MATLAB 代码进行处理,该代码完全独立于轮廓仪软件。首先从未经处理的地形中确定巩膜不对称性,然后在去除边缘效应噪声后再次确定。巩膜周围的地形被水平化,然后使用稳健的统计移动中位数技术消除边缘效应。除了比较原始高程数据外,还通过为每个巩膜表面拟合一个球体,并从最佳拟合球体参考表面确定相对高程,来比较巩膜的高程。

结果

当考虑半径 8mm 处巩膜部分的平均原始地形高程数据时,右眼巩膜的平均原始高程分别为-1.5±1.77、-1.87±2.12、-1.36±1.82 和-1.57±1.87mm。在同一半径处左眼的平均原始高程分别为-1.62±1.78、-1.82±2.07、-1.28±1.76 和-1.68±1.93mm。然而,当考虑去除边缘效应后的平均原始巩膜高程时,右眼的平均原始高程分别为-3.71±0.25、-4.06±0.23、-3.95±0.19 和-3.95±0.23mm。在同一半径处左眼的平均原始高程分别为-3.71±0.19、-3.97±0.22、-3.96±0.19 和-3.96±0.18mm,分别位于鼻侧、颞侧、上侧和下侧。右眼平均原始巩膜高程的最大原始高程不对称性为 1.6647±0.9015mm,左眼为 1.0358±0.6842mm,均在-38°的鼻侧检测到。基于最佳拟合球体的相对高程表明,在右眼的-40°、76°和 170°三个主要子午线上,以及左眼的-40°、76°和 170°三个主要子午线上,巩膜的高度更高,所有这些都是从鼻子午线测量的。右眼最大记录的相对高程不对称性分别为 76°和 63.5°角的 0.0844±0.0355mm 和 0.068±0.0607mm,左眼分别为 0.0844±0.0355mm 和 0.068±0.0607mm。

结论

如果不考虑从地形数据中去除边缘效应的方法,就不可能使用角膜巩膜地形数据来预测巩膜形状。巩膜的鼻侧高于颞侧,因此,旋转对称的巩膜接触镜更有可能向颞侧移动。巩膜的形状最好用水平化的原始高程来描述,而不是相对高程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a8/6660081/3f7124bfafda/pone.0219789.g001.jpg

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