小RNA找到了新靶点：通过靶向基因下游的非编码序列来调控基因表达。
Small RNAs hit a new target: Modulation of gene expression by targeting the non-coding sequences downstream from a gene.
作者信息
Demidov Vadim V
机构信息
Global Prior Art, Inc.; Boston, MA USA.
出版信息
Artif DNA PNA XNA. 2010 Oct;1(2):64-65. doi: 10.4161/adna.1.2.13945.
Abstract
The University of Texas researchers have recently discovered that small synthetic RNAs (sRNAs) that are complementary to sequences located 3'-outside of genes can efficiently modulate gene expression. These new findings significantly expand the transcription-regulatory potential of sRNAs, and they also may provide useful leads for other artificial nucleobase oligomers to target sequences beyond the 3' termini of mRNA.
摘要
德克萨斯大学的研究人员最近发现，与基因3'端外侧序列互补的小合成RNA（sRNA）能够有效调节基因表达。这些新发现显著扩展了sRNA的转录调控潜力，也可能为其他人工核碱基寡聚物靶向mRNA 3'端以外的序列提供有用线索。
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