在COP I背景下的GAPs：是酶、衣被组件还是两者皆是？
GAPs in the context of COPI: Enzymes, coat components or both?
作者信息
Beck Rainer, Brügger Britta, Wieland Felix
机构信息
Department of Cell Biology; Yale University School of Medicine; New Haven, CT USA.
出版信息
Cell Logist. 2011 Mar;1(2):52-54. doi: 10.4161/cl.1.2.15174.
Abstract
TRAFFICKING IN THE EARLY SECRETORY PATHWAY AT FIRST GLANCE IS WELL UNDERSTOOD ACCORDING TO TEXTBOOK KNOWLEDGE
To achieve secretion and to maintain organelle homeostasis, protein and lipid cargo need to be transported constitutively from their origins of biosynthesis to their respective destinations. Thus, secretory cargo exits the ER and is shuttled to the Golgi via vesicular COPII carriers. Lipid and protein cargo is enzymatically modified in the Golgi, transported from cis- to trans- (by mechanisms that are still debated today), and from there travel to their final destinations. The best established roles for COPI vesicles, simply spoken, is to mediate retrograde trafficking of cargo molecules that were transported forward, but need to be transported back.
摘要
乍一看，根据教科书知识，早期分泌途径中的转运过程已被充分理解：为了实现分泌并维持细胞器的稳态，蛋白质和脂质货物需要从其生物合成的起点持续运输到各自的目的地。因此，分泌货物离开内质网，并通过COPII囊泡载体转运至高尔基体。脂质和蛋白质货物在高尔基体中进行酶促修饰，从顺面运输到反面（其机制至今仍存在争议），并从那里前往它们的最终目的地。简单来说，COPI囊泡最明确的作用是介导已向前运输但需要运回的货物分子的逆行转运。
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