高尔基复合体顺面的进入和输出机制。
Entry and exit mechanisms at the cis-face of the Golgi complex.
机构信息
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a005207. doi: 10.1101/cshperspect.a005207.
Abstract
Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi compartments. The forward transport pathway to cis-Golgi compartments is balanced by a retrograde directed pathway that recycles transport machinery back to the ER. How trafficking through the ERGIC and cis-Golgi is coordinated to maintain organelle structure and function is poorly understood and highlights central questions regarding trafficking routes and organization of the early secretory pathway.
摘要
蛋白质和脂类货物从内质网 (ER) 到顺面高尔基体隔室的囊泡运输依赖于衣壳蛋白复合物、Rab GTPases、 tethering 因子和膜融合催化剂。ER 来源的囊泡将货物运送到内质网-高尔基体中间区室 (ERGIC)，然后与顺面高尔基体隔室融合和/或成熟。顺面高尔基体隔室的正向运输途径由逆行定向途径平衡，该途径将运输机制再循环回 ER。ERGIC 和顺面高尔基体之间的运输如何协调以维持细胞器的结构和功能尚不清楚，这突显了有关运输途径和早期分泌途径组织的核心问题。
相似文献
1
Entry and exit mechanisms at the cis-face of the Golgi complex.高尔基复合体顺面的进入和输出机制。
Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a005207. doi: 10.1101/cshperspect.a005207.
2
ER-to-Golgi transport: COP I and COP II function (Review).内质网到高尔基体的运输：COP I和COP II的功能（综述）
Mol Membr Biol. 2003 Jul-Sep;20(3):197-207. doi: 10.1080/0968768031000122548.
3
COPII-mediated trafficking at the ER/ERGIC interface.内质网/内质网相关复合体内 COPII 介导的物质运输。
Traffic. 2019 Jul;20(7):491-503. doi: 10.1111/tra.12654. Epub 2019 May 30.
4
The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi.高度保守的 COPII 被膜小泡复合物从内质网分拣货物，并将其靶向高尔基体。
Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2):a013367. doi: 10.1101/cshperspect.a013367.
5
Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering.Rab1与GM130效应复合物的相互作用调节COPII囊泡与顺式高尔基体的拴系。
Traffic. 2001 Apr;2(4):268-76. doi: 10.1034/j.1600-0854.2001.1o007.x.
6
Reconstitution of COPII vesicle fusion to generate a pre-Golgi intermediate compartment.COPI囊泡融合的重组以生成高尔基体前中间区室。
J Cell Biol. 2004 Dec 20;167(6):997-1003. doi: 10.1083/jcb.200408135.
7
The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle.早期分泌途径对丙型肝炎病毒生命周期的多个方面至关重要。
J Virol. 2023 Jul 27;97(7):e0018023. doi: 10.1128/jvi.00180-23. Epub 2023 Jun 20.
8
The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.货物受体Surf4、内质网-高尔基体中间腔室（ERGIC）-53和p25是维持ERGIC和高尔基体结构所必需的。
Mol Biol Cell. 2008 May;19(5):1976-90. doi: 10.1091/mbc.e07-10-0989. Epub 2008 Feb 20.
9
The plant ER-Golgi interface.植物内质网-高尔基体界面
Traffic. 2008 Sep;9(10):1571-80. doi: 10.1111/j.1600-0854.2008.00773.x. Epub 2008 Jun 28.
10
Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export.内质网到高尔基体转运载体的生物发生：COPII在内质网输出中的复杂作用。
Trends Cell Biol. 2004 Feb;14(2):57-61. doi: 10.1016/j.tcb.2003.12.001.
引用本文的文献
1
Golgi Dysfunctions in Ciliopathies.高尔基复合体在纤毛病中的功能障碍。
Cells. 2022 Sep 6;11(18):2773. doi: 10.3390/cells11182773.
2
How Viruses Hijack and Modify the Secretory Transport Pathway.病毒如何劫持和修饰分泌转运途径。
Cells. 2021 Sep 24;10(10):2535. doi: 10.3390/cells10102535.
3
The PKD-Dependent Biogenesis of TGN-to-Plasma Membrane Transport Carriers.PKD 依赖性 TGN 至质膜运输载体的生物发生。
Cells. 2021 Jun 28;10(7):1618. doi: 10.3390/cells10071618.
4
Sec17 (α-SNAP) and Sec18 (NSF) restrict membrane fusion to R-SNAREs, Q-SNAREs, and SM proteins from identical compartments.Sec17（α-SNAP）和 Sec18（NSF）将膜融合限制在来自相同隔室的 R-SNAREs、Q-SNAREs 和 SM 蛋白上。
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23573-23581. doi: 10.1073/pnas.1913985116. Epub 2019 Nov 4.
5
New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.通过全基因组 CRISPRi 筛选鉴定哺乳动物细胞中蛋白质转运的新因子。
J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5.
6
A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways.一种导致 ATLASTIN 3 突变的疾病会影响多种与内质网相关的途径。
Cell Mol Life Sci. 2019 Apr;76(7):1433-1445. doi: 10.1007/s00018-019-03010-x. Epub 2019 Jan 21.
7
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.2 型脱碘酶多态性导致大脑内质网应激和甲状腺功能减退。
J Clin Invest. 2019 Jan 2;129(1):230-245. doi: 10.1172/JCI123176. Epub 2018 Dec 3.
8
Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system.中间区室（IC）：从前高尔基体囊泡到一个半自主膜系统。
Histochem Cell Biol. 2018 Nov;150(5):407-430. doi: 10.1007/s00418-018-1717-2. Epub 2018 Sep 1.
9
Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While: Evolution of the metazoan early secretory pathway.细胞器接口处的早期分泌途径中的膜转运：脱外套并稍作停留：后生动物早期分泌途径的演化。
Bioessays. 2018 Jul;40(7):e1800004. doi: 10.1002/bies.201800004. Epub 2018 May 9.
10
Stacks off tracks: a role for the golgin AtCASP in plant endoplasmic reticulum-Golgi apparatus tethering.脱离轨道的堆栈：高尔基体蛋白AtCASP在植物内质网-高尔基体系链中的作用
J Exp Bot. 2017 Jun 15;68(13):3339-3350. doi: 10.1093/jxb/erx167.
本文引用的文献
1
Models for Golgi traffic: a critical assessment.高尔基运输模型：批判性评估。
Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a005215. doi: 10.1101/cshperspect.a005215.
2
COPI budding within the Golgi stack.内质网腔中 COPI 小泡的出芽。
Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a005231. doi: 10.1101/cshperspect.a005231.
3
Organization of SNAREs within the Golgi stack.内质网中 SNARE 的组织。
Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a005249. doi: 10.1101/cshperspect.a005249.
4
The golgin coiled-coil proteins of the Golgi apparatus.高尔基体卷曲螺旋蛋白。
Cold Spring Harb Perspect Biol. 2011 Jun 1;3(6):a005256. doi: 10.1101/cshperspect.a005256.
5
The yeast GRASP Grh1 colocalizes with COPII and is dispensable for organizing the secretory pathway.酵母 GRASP Grh1 与 COPII 共定位，对于组织分泌途径不是必需的。
Traffic. 2010 Sep;11(9):1168-79. doi: 10.1111/j.1600-0854.2010.01089.x. Epub 2010 Jun 21.
6
Arf GAPs: gatekeepers of vesicle generation.Arf GAPs：囊泡生成的守门员。
FEBS Lett. 2010 Jun 18;584(12):2646-51. doi: 10.1016/j.febslet.2010.04.005. Epub 2010 Apr 13.
7
The role of GRASP65 in Golgi cisternal stacking and cell cycle progression.GRASP65 在高尔基池堆叠和细胞周期进程中的作用。
Traffic. 2010 Jun;11(6):827-42. doi: 10.1111/j.1600-0854.2010.01055.x. Epub 2010 Feb 27.
8
Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis.有丝分裂中 ARF 交换因子 GBF1 的磷酸化和膜解离。
Biochem J. 2010 Apr 14;427(3):401-12. doi: 10.1042/BJ20091681.
9
Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease.大型Arf1鸟嘌呤核苷酸交换因子：进化、结构域结构及其在膜运输和人类疾病中的作用
Mol Genet Genomics. 2009 Oct;282(4):329-50. doi: 10.1007/s00438-009-0473-3. Epub 2009 Aug 11.
10
The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.Syntaxin Tlg2p的N端肽段调节其封闭构象与Vps45p的结合。
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14303-8. doi: 10.1073/pnas.0902976106. Epub 2009 Aug 10.
Zotero 插件