内质网-高尔基体接口处的 COPII 和 COPI 运输。
COPII and COPI traffic at the ER-Golgi interface.
机构信息
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Physiology (Bethesda). 2011 Oct;26(5):348-64. doi: 10.1152/physiol.00017.2011.
Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly synthesized secretory proteins destined to the secretory and endolysosmal systems are transported from the endoplasmic reticulum to the Golgi before delivery to their final destinations. Here, we describe the COPII and COPI coating machineries that generate carrier vesicles and the tethers and SNAREs that mediate COPII and COPI vesicle fusion at the ER-Golgi interface.
蛋白质运输对于所有真核生物的维持内稳态都是必需的。所有新合成的分泌蛋白，其目的地是分泌和内溶酶体系统，都在递送到最终目的地之前从内质网运输到高尔基体。在这里，我们描述了 COPII 和 COPI 包被机器，它们产生载体囊泡，以及连接蛋白和 SNARE 介导 COPII 和 COPI 囊泡在 ER-Golgi 界面融合。
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