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本文引用的文献

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A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network.一项关于初诊为婴儿暂时性低丙种球蛋白血症患儿的前瞻性研究：来自意大利原发性免疫缺陷网络的结果。
Int J Immunopathol Pharmacol. 2008 Apr-Jun;21(2):343-52. doi: 10.1177/039463200802100211.
2
The four most common pediatric immunodeficiencies.四种最常见的儿科免疫缺陷。
Adv Exp Med Biol. 2007;601:15-26. doi: 10.1007/978-0-387-72005-0_2.
3
Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens.用于直接从原始临床标本中鉴定所有肠道病毒血清型的VP1序列的灵敏半巢式PCR扩增。
J Clin Microbiol. 2006 Aug;44(8):2698-704. doi: 10.1128/JCM.00542-06.
4
Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection.婴儿期短暂性低丙种球蛋白血症表现为金黄色葡萄球菌败血症伴颈部深部感染。
J Microbiol Immunol Infect. 2005 Apr;38(2):141-4.
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Symptomatic hypogammaglobulinemia in infancy and childhood - clinical outcome and in vitro immune responses.婴幼儿期和儿童期有症状的低丙种球蛋白血症——临床结局和体外免疫反应
BMC Fam Pract. 2004 Oct 21;5:23. doi: 10.1186/1471-2296-5-23.
6
A case of IgG subclass deficiency with the initial presentation of transient hypogammaimmuno-globulinemia of infancy and a review of IgG subclass deficiencies.一例以婴儿期短暂性低丙种球蛋白血症为首发表现的IgG亚类缺陷病例及IgG亚类缺陷综述
J Med Assoc Thai. 2003 Jul;86(7):686-92.
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An infant with encephalitis.
Lancet. 1997 Nov 29;350(9091):1594. doi: 10.1016/s0140-6736(97)09514-7.
8
X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy.
J Allergy Clin Immunol. 1995 Apr;95(4):915-7. doi: 10.1016/s0091-6749(95)70138-9.
9
Chronic enteroviral meningoencephalitis in agammaglobulinemia: case report and literature review.无丙种球蛋白血症中的慢性肠道病毒性脑膜脑炎：病例报告及文献综述
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Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up.
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复发性肠道病毒脑炎：偶然因素还是其他原因？

Recurrent enterovirus encephalitis: chance or something else?

作者信息

Cheng Frankie Wai Tsoi, Chan Paul K S, Ho Wendy C S, Wong Felix Y W, Leung T F

机构信息

Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Paediatrics, Shatin, New Territories, Hong Kong.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.12.2008.1358. Epub 2009 Jun 3.

DOI:10.1136/bcr.12.2008.1358
PMID:21686352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3028059/
Abstract

A 22-month-old boy presented with repeated enterovirus infections including two episodes of encephalitis at the age of 8 months and 16 months and two episodes of febrile illnesses at 14 and 19 months old. These episodes were associated with at least two different serotypes of enterovirus. There were no residual neurological deficits and he underwent complete recovery in between. Immunology workup showed normal circulating leucocyte differential counts and lymphocyte subsets. His serum IgG concentration was persistently low but could mount satisfactory specific antibody responses to booster vaccines. The clinical picture was compatible with transient hypogammaglobulinaemia of infancy (THI) which was traditionally believed not to be associated with serious viral infections. This is the first case report to alert physicians that repeated serious enterovirus infections can happen in a relatively benign immunodeficiency disease.

摘要

一名22个月大的男孩反复感染肠道病毒，包括在8个月和16个月时发生的两次脑炎，以及在14个月和19个月时发生的两次发热性疾病。这些发作与至少两种不同血清型的肠道病毒有关。其间没有残留神经功能缺损，他完全康复。免疫检查显示循环白细胞分类计数和淋巴细胞亚群正常。他的血清IgG浓度持续偏低，但对加强疫苗能产生令人满意的特异性抗体反应。临床表现符合婴儿期短暂性低丙种球蛋白血症（THI），传统上认为该疾病与严重病毒感染无关。这是首例提醒医生反复严重肠道病毒感染可发生于相对良性免疫缺陷病的病例报告。