4例肺移植后囊性纤维化患者发生假膜性结肠炎。
Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation.
作者信息
Yates B, Murphy D M, Fisher A J, Gould F K, Lordan J L, Dark J H, Corris P A
机构信息
Institute of Cellular Medicine, University of Newcastle and The Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1218. Epub 2009 May 8.
Abstract
In the present study, 4 patients with cystic fibrosis undergoing lung transplantation (from a total of 137) who developed fulminant pseudomembranous colitis are described. Initial presentation was variable and the mortality rate was 50% despite urgent colectomy. In one case the presenting abdominal distension was thought to be due to meconium ileus equivalent. It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation.
摘要
在本研究中，描述了4例接受肺移植的囊性纤维化患者（总共137例患者中）发生暴发性假膜性结肠炎的情况。初始表现各不相同，尽管进行了紧急结肠切除术，但死亡率仍为50%。在1例病例中，最初出现的腹胀被认为是由于胎粪性肠梗阻等效物所致。得出的结论是，艰难梭菌结肠炎在囊性纤维化患者中可能难以诊断，并且在肺移植后呈暴发性病程。
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