Peach S L, Borriello S P, Gaya H, Barclay F E, Welch A R
J Clin Pathol. 1986 Sep;39(9):1013-8. doi: 10.1136/jcp.39.9.1013.
Faecal samples from 37 patients with cystic fibrosis and 40 control patients at the Brompton Hospital and the London Chest Hospital were examined for the presence of Clostridium difficile. The organism was isolated from 2 (17%) of control patients who were receiving antibiotics and from one (3.6%) of control patients who had no antimicrobial treatment. Thirty two per cent of the patients with cystic fibrosis excreted C difficile, though none of them had diarrhoea. Two of the three isolates from control patients and nine of the 12 isolates from patients with cystic fibrosis produced toxin B (cytotoxin) in vitro. Toxin B was present in the stools of one of the control patients and three of the patients with cystic fibrosis; toxin A (enterotoxin) was not detected in the faeces of the patients with cystic fibrosis. Two cytotoxigenic strains of C difficile isolated from patients with cystic fibrosis were examined in hamsters; both were virulent, and the animals died.
对来自布朗普顿医院和伦敦胸科医院的37例囊性纤维化患者及40例对照患者的粪便样本进行艰难梭菌检测。在接受抗生素治疗的2例（17%）对照患者及未接受抗菌治疗的1例（3.6%）对照患者中分离出该菌。32%的囊性纤维化患者排出艰难梭菌，不过他们均无腹泻症状。对照患者分离出的3株菌中有2株以及囊性纤维化患者分离出的12株菌中有9株在体外产生毒素B（细胞毒素）。1例对照患者和3例囊性纤维化患者的粪便中存在毒素B；在囊性纤维化患者的粪便中未检测到毒素A（肠毒素）。对从囊性纤维化患者中分离出的2株产细胞毒素的艰难梭菌菌株在仓鼠体内进行检测；二者均具有毒性，动物死亡。
