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Fatal pulmonary Mycobacterium xenopi in a patient with rheumatoid arthritis receiving etanercept.一名接受依那西普治疗的类风湿关节炎患者发生致命性肺部偶发分枝杆菌感染。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.0967. Epub 2009 Feb 2.
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本文引用的文献

1
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management.抗肿瘤坏死因子药物与结核病风险：作用机制及临床管理
Lancet Infect Dis. 2003 Mar;3(3):148-55. doi: 10.1016/s1473-3099(03)00545-0.
2
Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases.用于治疗风湿性疾病的肿瘤坏死因子-α拮抗剂。
Curr Opin Rheumatol. 2002 May;14(3):204-11. doi: 10.1097/00002281-200205000-00002.
3
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.与英夫利昔单抗（一种肿瘤坏死因子α中和剂）相关的结核病。
N Engl J Med. 2001 Oct 11;345(15):1098-104. doi: 10.1056/NEJMoa011110.
4
Mycobacterium xenopi: innocent bystander or emerging pathogen?偶发分枝杆菌：无辜旁观者还是新兴病原体？
Clin Infect Dis. 1997 Feb;24(2):226-32.

一名接受依那西普治疗的类风湿关节炎患者发生致命性肺部偶发分枝杆菌感染。

Fatal pulmonary Mycobacterium xenopi in a patient with rheumatoid arthritis receiving etanercept.

作者信息

Maimon Nimrod, Brunton James, Chan Adrienne, Marras Theodore K

机构信息

Soroka University Medical Center, Beer-Sheva, Beer-Sheva, Beer-Sheva, Israel.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.0967. Epub 2009 Feb 2.

DOI:10.1136/bcr.09.2008.0967
PMID:21686534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027497/
Abstract

In this case study, a 71 year old man with emphysema and severe rheumatoid arthritis, previously treated with a TNFα receptor antagonist, presented with progressive dyspnoea and weight loss. Thoracic imaging revealed extensive destruction of the left lung and this was associated with positive Mycobacterium xenopi cultures from respiratory samples. Anti-mycobacterial chemoptherapy was poorly tolerated and the patient subsequently died from respiratory failure and generalised wasting.

摘要

在本病例研究中，一名71岁患有肺气肿和严重类风湿性关节炎的男性，此前接受过肿瘤坏死因子α受体拮抗剂治疗，出现进行性呼吸困难和体重减轻。胸部影像学检查显示左肺广泛破坏，且呼吸道样本中偶发分枝杆菌培养呈阳性。抗分枝杆菌化疗耐受性差，患者随后死于呼吸衰竭和全身消瘦。